Work on evaluation of crop mixtures for the management of cotton pests has shown beans to be a suitable intercrop that can augement the numbers of gerneralist predators in the cropping systems of E. Uganda. Incidence of generalist predators in the cotton - bean intercrop shows spiders to be more numerous (57%) as compared to other predators combined (43%). In the cotton- maize intercrop spiders are less numerous (29%) than other predators combined (71%). On cotton bordered by maize the number of spiders is about the same as in the cotton-maize-intercrop. The common predators on cotton bordered by sorghum include 30% spiders. The role of spiders in the regulation of pests in cotton cropping systems is discussed.